With the support of both microscopy and artificial intelligence, the”E-Morph” test faithfully identifies substances which could have oestrogen-like or perhaps conflicting consequences, according to the study group’s report at the professional journal”Environment International”. “E-Morph is a milestone on how to, one afternoon, substituting animal experiments now required to discover hormone-like effects,” states BfR President Prof. Dr. Dr. Andreas Hensel.
The evaluation relies upon the observation that compounds with an oestrogen-like impact can loosen the link between cells from the adrenal gland. This makes it a lot easier for breast cancer cells to detach from the tissue – a vital step in the spreading (metastasis) of tumours. From the E-Morph evaluation, a test chemical is given to cultured human breast cancer cells.
The cells are then analyzed to discover if the mobile contacts loosen as though under the effect of oestrogen. This result isn’t hard to observe under the microscope and may be assessed entirely automated with artificial intelligence. The robot-assisted test involving evaluation is fast and empowers many materials to be analyzed in limited time.
Possible future uses of this test include testing compounds that have been promoted in addition to those which are going to be established. The evaluation may also be employed to create new medications, enhance diagnostic tests to detect breast cancer, and reevaluate treatments.
It guides the German national authorities and German federal states (“Laender”) about questions of food, product and chemical safety. The BfR conducts its own research on subjects which are closely connected to its evaluation tasks.
It coordinates all actions nationally with the aims of restricting animal experiments to just those that are deemed necessary, and assuring the finest possible protection for lab animals. What’s more, it plans to stimulate research activities and promote scientific dialogue.